WLS Wnt ligand secretion mediator

Gene info

Synonyms

FLJ23091, MRP, wls, EVI, mig-14

Previous symbol

C1orf139, GPR177

External ID

HGNC: 30238
Entrez Gene: 79971
Ensembl: ENSG00000116729
UCSC: uc001def.3
OMIM: 611514
UniProtKB: Q5T9L3

Disease info

Disease

None

CHD Phenotype

  • Patent ductus arteriosus
  • Patent foramen ovale

Extra Cardiac Phenotype

Microcephaly, facial dysmorphism, foot syndactyly, renal agenesis, alopecia, iris coloboma

Incomplete penetrance

Unknown

Variable expressivity

Unknown

Animal model

Mouse study

MGI: Homozygous null mice are embryonic lethal

MGI ID

1915401

Variant info

Clinvar

WLS

Selected variant

The Clinvar variants presented in the below IGV track were selected based on the following criteria.

  1. Variant types are single nucleotide variant or Indel
  2. Clinical significance for the variant was assessed to be Pathogenic or Likely Pathogenic
  3. ClinVar review status for the variant is criteria provided

No variant passing our criteria was found for WLS.

Selected References

  1. Chai, G., Szenker-Ravi, E., Chung, C., Li, Z., Wang, L., Khatoo, M., Marshall, T., Jiang, N., Yang, X., McEvoy-Venneri, J., Stanley, V., Anzenberg, P., Lang, N., Wazny, V., Yu, J., Virshup, D. M., Nygaard, R., Mancia, F., Merdzanic, R., … Gleeson, J. G. (2021). A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. New England Journal of Medicine, 385(14), 1292–1301. https://doi.org/10.1056/nejmoa2033911 DOI:10.1056/NEJMoa2033911 PMID:34587386